Foli-seq™ profiles host RNA from epithelial and immune cells shed into stool, providing a non-invasive window into local gut biology across inflammation, barrier function, tissue injury, repair, and therapeutic response.
The intestinal mucosa continuously sheds epithelial and immune cells into stool. These exfoliated host cells carry RNA signatures that reflect local tissue programs, including inflammation, barrier function, epithelial state, injury, repair, and treatment response. Foli-seq™ captures this stool-derived host RNA to provide a non-invasive transcriptomic readout of host gut biology.
Foli-seq™ is built on peer-reviewed work demonstrating that stool-derived host RNA can capture transcriptomic signals from exfoliated intestinal cells and provide a non-invasive readout of gut mucosal biology.
This study established the scientific foundation for profiling host RNA from exfoliated intestinal cells in stool, supporting non-invasive measurement of mucosal inflammation, epithelial state, immune activity, and longitudinal gut biology.
Foli-seq™ profiles host RNA from naturally shed gut epithelial and immune cells present in stool. Unlike microbiome sequencing, which measures microbial DNA or RNA, Foli-seq™ captures the host response at the gut lining — including immune signaling, epithelial state, barrier function, tissue injury, repair biology, therapeutic response, and polyp- or adenoma-associated changes.
Foli-seq™ panels profile stool-derived host RNA across immune activation, epithelial barrier function, tissue injury, repair biology, therapeutic response, and polyp- or adenoma-associated biology.
Human and murine panels share a tiered architecture to support translation from preclinical models to human studies. Companion animal panels extend the platform to canine and feline GI biology. Gene-level panel information can be explored in the Panel Browser below.
Focused host immune and inflammatory profiling across immune signaling, cytokine and chemokine response, epithelial immune crosstalk, and therapeutic response biology.
Broad coverage of epithelial, barrier, mucus, metabolic, injury, and repair biology in the gut mucosa, enabling deeper profiling of local host functional state.
Expanded host transcriptomic profiling for discovery biology, molecular signature development, patient subgroup discovery, biomarker modeling, and target discovery.
Targeted host immune profiling for murine models of gut inflammation, immune perturbation, microbiome intervention, and therapeutic response.
Broad profiling of epithelial barrier biology, mucus and goblet cell programs, tissue injury, repair biology, nutrient transport, metabolic response, and model-state biology in murine gut models.
Core host gut biology panel for canine GI inflammation, epithelial injury, barrier function, repair biology, treatment response, and functional state.
Core host gut biology panel for feline GI inflammation, epithelial injury, barrier function, repair biology, treatment response, and functional state.
Contact Foli Bio to learn more about companion animal GI applications.
Explore genes included in human, murine, canine, and feline Foli-seq™ panels. Filter by panel, gene symbol, gene ID, transcript ID, or description.
| Species | Panel | Ensembl Gene ID | Ensembl Gene Symbol | Ensembl Transcript ID | Description |
|---|---|---|---|---|---|
| Select a panel above to browse genes. | |||||
Foli-seq™ provides standard and custom panel options across human translational studies, murine preclinical models, and companion animal GI research.